According to ESRB, this game contains: Blood and Gore, Intense Violence, Strong Language, Strong Sexual Content, Use of Drugs

Parents, are you seriously considering buying this for your children under the age of 17? Seriously? You know that this is the sequel to the only PS2/Xbox game to feature full frontal male nudity, right? And that it's themed around dangerous brain surgery that turns regular people into psychopathic killers? And that the game moves to such memorable locales as a snuff club, porno theatre, and adult video store? And if all that hasn't dissuaded you from buying this for your children, feel free to call your local police department and turn yourself in for child endangerment right now.
Fans of the first Manhunt will find this game the ultimate mixed bag. The story is a great improvement over the first, but the voice acting is a small step down. There's a much wider variety of kills, but none of them are actually visible. If you're a fan of the first, it's worth a try, but be forewarned, there's nothing as good as the Piggsy fight to be found anywhere on the disc.
Deaf and Hard of Hearing gamers should be okay. You'll miss out on most of the incidental dialogue, but get the story delivered in subtitles. An onscreen radar means that you'll always be able to tell where your enemies are, so you won't have to rely on hearing them coming.
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