According to the ESRB, this game contains: Blood, Mild Language, Mild Violence, Partial Nudity
Parents shouldn't be too concerned. The "partial nudity" referred to on the box is laughable—during a few operations, the lower curve of a pair of unobtrusive breasts can be made out at the very top edge of the screen. It's easy to miss, really, and barely more than two pink arcs. Naturally there's a bit of blood since this IS a surgery game, and you can't really operate without seeing some red stuff. I can't really figure out what the violence is since I don't think the operations count, and there's only one brief scene in the whole game that features a small altercation, it's all of two frames and nobody even gets shot. The language is negligible… not anything even worth mentioning. I suppose the ESRB is getting highly sensitive these days and erring on the side of over-caution. It's a hard game, but nothing that will corrupt your kids. They may even learn something from it what with all the medical terms and talk of responsibility.
DS Gamers, just go buy it. If you have a DS for the sake of new experiences and innovative gameplay, here you go. 'Nuff said.
Niche Gamers… same advice I gave to the DS gamers. You need to buy it also, and do it fast. Atlus games are famous for becoming high-priced horrors on eBay.
Deaf and Hard of Hearing gamers get full text for all conversation in-game. However, during tense procedures it's sometimes easier to hear when something happens than to read about it on the upper screen. It's still playable (I did it myself with the sound off for about half of the game) but you're going to have to really pay attention to your peripheral vision in order to see some of the cues given by the nurse up top. Still, I would say that it's equally accessible in the vast majority of play.