According to the ESRB, this game contains: Cartoon Violence, Crude Humor, Language
Parents might want to be cautious about letting very young gamers play Psychonauts. Along with several instance of bad language and some very minor sexual themes—Raz and his girlfriend Lili talk about "making out" and kiss on the lips—this game deals with mental illness and dysfunctional families, which might be disturbing for young children. For example, one of Raz's tasks is to save bunnies from an evil butcher, who comes after him with meat cleavers.
Invader Zim fans will recognize Richard S. Horvitz as the voice of Raz, although he doesn't say "Obey the fist!"
Deaf and Hard of Hearing gamers can turn on subtitles in the audio options. While they shouldn't have too many problems playing Psychonauts, they won't be able to hear the scuttling of the exploding rats in the asylum or the sobbing of the "emotional baggage" found throughout the game. Both sounds are handy for telling players where these things are.