Since I know Platinum Games is on it:
Metal Gear Rising - Revengenance! Please let it be as awesome as Vanquish
Since DXHR was pretty good, I'm also looking forward to
Dishonored. Let's see how far the new range of deus ex-like games will go.
Furthermore two indie tactics games:
Fray http://www.fray-game.com/ and
Xenonauts http://www.xenonauts.com/
I am also carefully excited about
Bioshock: Infinite,
Dragon's Dogma and
Mass Effect 3.