The ESRB reports that this game contains: Blood and Gore, Intense Violence, Language, Sexual Themes
Parents probably shouldn't buy this for their children. In addition to all the violence, mature themes, and predatory homosexuals, your under-16s probably just don't have the attention span and reasoning ability to understand the game's complex and layered plot, which would massively lessen their enjoyment of the game. Although, as always, the murdering content is top-notch.
Metal Gear Solid Fans will love this. MGS3 was the best game in the series, and the adjustments that have been made to the camera system have made it far more accessible than it already was. Not only is this a wonderful game for fans of the series, but a perfect place for newcomers to jump in to the series.
Deaf and hard of hearing gamers have a bit of a mixed bag. Being able to hear opponents is vitally important, and while there are items in the game that allow players to do without hearing, such as a limited radar and motion detector, as well as incidental dialogue subtitling, on the higher difficulties these are unavailable, making the game all but unplayable for the hearing-impaired. Also, the codec conversations that provide most of the game's plot offer no way of telling which of the two characters onscreen is speaking, which can get confusing rather quickly.